Stapled peptides introduce a covalent brace that can stabilize alpha-helical conformation. These tools are used in protein–protein interaction research and chemical biology.
ChinaPeptides reviews staple position, olefin chemistry and purification requirements before synthesis.
Staple placement is part of the design, not a decoration. i, i+4 and i, i+7 geometries are common starting points. The inquiry should name the residues to replace and whether the unstapled linear analogue is also required as a control.
A staple does not make a peptide a drug. These materials remain research tools with HPLC and MS documentation of the closed product.